Fifth Avenue Forum

89-year old ( ) Michael Atiyah (who won the Math "Nobel Prize" in 1966) just announced that he found the solution of Riemann Hypothesis (https://www.claymath.org/millennium-pro ... hypothesis) - one of the currently unsolved "Millenium Problems":

https://www.newscientist.com/article/21 ... ypothesis/

If you are in Heidelberg on September 24 - the presentation of the proof starts at 9:45 AM CET!

https://www.heidelberg-laureate-forum.org/event_2018/

You were recently invited to review the above manuscript, but we have not yet received your reply. Because of production and time restrictions, we must now proceed with evaluating this manuscript without your input.

I hope that we may have the privilege of using your services in the future when the timing is more convenient.

Yours sincerely,

XXXXX Ph.D.
Guest Editor
Journal of {Something}

Researchers have rendered a population of mosquitoes in a lab sterile using the gene-editing tool CRISPR-Cas9 by homing in on a specific target in insect DNA -- the doublesex gene -- raising the possibility of eradicating disease-carrying species of the insect entirely, according to a new study published Monday in Nature Biotechnology.

What do they do that we would miss?

The study has not been presented at a scientific conference, published in a peer-reviewed journal or registered with a regulatory agency. In their press release, Zion Medical describe the mode of action as follows. “Gammora is a synthetic peptide compound derived from the HIV enzyme integrase, which is responsible for inserting the virus's genetic material into the DNA of the infected cell. Gammora stimulates the integration of multiple HIV DNA fragments into the host cell's genomic DNA, to an extent that triggers the self-destruction of the infected cell, called apoptosis.”

The drug appears to be a broad-spectrum disrupter of viral replication (like ribavirin, a drug previously used in hepatitis C treatment). It might work to limit viral proliferation in established infection and the infection of further cells (as other antiretroviral drugs do).

However, there is no reason it would be active against the reservoir of latently infected cells (which already contain integrated HIV DNA). If it could cure, it would need to be active against the latent reservoir.

“The HIV world has seen quackery in different forms for decades – sadly this smacks of more of it,” Professor Francois Venter of the University of Witwatersrand, South Africa commented.

“I looked at the press report and the unsophisticated company website, and even if you believe their claims, they are many years away from testing them,” he said. “This gives science and scientists a bad name.”

Just like Harvard "researchers" saying an alien probe might have passed us last year.

Just like Harvard "researchers" saying an alien probe might have passed us last year.

That's not a big deal to me... it doesn't really have any impact on everyday lives. There aren't a significant portion of the population out there that are anxiously waiting to get their hands on said alien probe like they are for a cure for HIV.

The unusual cross-breed has the plumage of two warbler species, sings like another and has been named after its discoverer.

Lowell Burket, a Pittsburgh attorney, is credited with finding the previously unknown three-species hybrid believed to be the result of a complicated genetic mix that ornithologists had never seen and didn’t think was possible.

New hybrid bird discovered near Altoona is like breeding a dog with a wolf and a fox: "This shouldn't happen"

The unusual cross-breed has the plumage of two warbler species, sings like another and has been named after its discoverer.

Lowell Burket, a Pittsburgh attorney, is credited with finding the previously unknown three-species hybrid believed to be the result of a complicated genetic mix that ornithologists had never seen and didn’t think was possible.

http://www.post-gazette.com/life/outdoo ... 1811160023

Ask medieval historian Michael McCormick what year was the worst to be alive, and he's got an answer: "536." Not 1349, when the Black Death wiped out half of Europe. Not 1918, when the flu killed 50 million to 100 million people, mostly young adults. But 536. In Europe, "It was the beginning of one of the worst periods to be alive, if not the worst year," says McCormick, a historian and archaeologist who chairs the Harvard University Initiative for the Science of the Human Past.

Scientists have been stumped by a 20-minute rumble of a mysterious seismic wave felt across the world